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In 116 patients suffering severe TBIdesaturations were predictive of poor neurological outcome (37).
In depressed patients who havepreponderance of REM sleep, this phase issuppressed and awakenings during night arereduced.
The recommendedstarting dose is 10 or 20 mg once a day in the evening. Also, fixed articulating spacers have been proposed, and they have shown asuccessful infection eradication rate and acceptable functional outcomes  Also, fixed articulating spacers have been proposed, and they have shown asuccessful infection eradication rate and acceptable functional outcomes .